NCT00943852

The Effect of Losartan and Losartan Plus Isosorbide Mononitrate on Central Blood Pressure Measurements (0954-317)

A Double-Blind, Randomized, Placebo-Controlled, 5-Period Crossover Study to Evaluate the Effects of a Single Dose of Losartan, a Single Dose of Isosorbide Mononitrate (ISMN), and Single Doses of Losartan + ISMN on Central Blood Pressure Measurements in Mildly Hypertensive Patients

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Organon and Co · Industry
• Sex: All
• Age: 45 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study will qualify a functional model that can measure central blood pressure and vascular compliance effects through noninvasive means.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	losartan potassium	Single dose losartan 100 mg in one of five treatment periods
DRUG	Comparator: isosorbide mononitrate (ISMN)	Single dose ISMN 60 mg in one of five treatment periods
DRUG	Comparator: losartan + ISMN	Single dose losartan 100 mg and ISMN 15 mg in one of five treatment periods
DRUG	Comparator: losartan + ISMN	Single dose losartan 100 mg and ISMN 60 mg in one of five treatment periods
DRUG	Comparator: Placebo	Single dose placebo only in one of five treatment periods

Timeline

• Start date: 2006-08-01
• Primary completion: 2006-12-01
• Completion: 2006-12-01
• First posted: 2009-07-22
• Last updated: 2022-02-09
• Results posted: 2010-07-15