NCT00942695

Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: United States Department of Agriculture (USDA) · Federal
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to measure the energy value of pistachios in the human diet and study molecular mechanisms that may help explain the beneficial health effects of pistachios.

Detailed description

Previous studies have suggested that nut consumption imparts a variety of health benefits, including reduction of cardiovascular disease and improved satiety. However, studies of pistachios are extremely limited. The aim of this study is to determine the energy value of pistachios in the human diet and to probe mechanisms by which pistachios impart health benefits. The metabolizable energy value of pistachio nuts will be calculated based on the chemical composition and energy content of the consumed diet and excreta. This will provide a better estimate of the energy value of pistachios than simply calculating energy value based on Atwater factors. In addition to determining the energy value of pistachios, we will evaluate the effects of pistachio-rich diets on plasma phytonutrient levels and on gene expression changes to determine what protective mechanisms are activated by pistachio consumption.

Conditions

• Energy
• Cardiovascular Disease
• Cancer

Interventions

Type	Name	Description
OTHER	1.5PD	average American diet plus 1.5 oz per day pistachios
OTHER	3.0PD	average American diet plus 3.0 oz per day pistachios
OTHER	control	average American diet without pistachios

Timeline

• Start date: 2009-10-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2009-07-21
• Last updated: 2011-02-09

Locations

1 site across 1 country: United States