NCT00942656

Effect of Trans Fatty Acids From Ruminant Sources on Risk Factors for Cardiovascular Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: United States Department of Agriculture (USDA) · Federal
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The objectives of this study are to : 1) determine if vaccenic acid (trans-11-octadecenoic, a naturally occurring trans fatty acid isomer from ruminant animal products) raises LDL cholesterol in a quantitatively comparable manner as mixed trans fatty acid isomers from partially hydrogenated vegetable oils at 3% of energy intake, 2) determine if cis-9, trans-11 conjugated linoleic acid (a naturally occurring polyunsaturated fatty acid from ruminant animal products) raises LDL cholesterol compared to a control diet, and 3) demonstrate that mixed trans fatty acid isomers from partially hydrogenated vegetable oil raises LDL cholesterol compared to a low trans fatty acid diet.

Conditions

• Cardiovascular Disease

Interventions

Type	Name	Description
OTHER	PHVO	base diet plus 3.0% energy mixed isomers of trans fatty acids from partially hydrogenated vegetable oil
OTHER	CLA	base diet plus 1.0% energy added from cis-9, trans-11 conjugated linoleic acid
OTHER	VA	base diet plus 3.0% energy added from vaccenic acid
OTHER	base	base diet containing approximately 0.1% energy of mixed trans fatty acid isomers

Timeline

• Start date: 2009-02-01
• Primary completion: 2009-09-01
• Completion: 2009-09-01
• First posted: 2009-07-21
• Last updated: 2011-02-09

Locations

1 site across 1 country: United States