NCT00940134

Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.

INGEAR-1: Effects of INtravenous Infusions of PYY3-36 and GLP-1, as Monoinfusion and in Combination, on ad Libitum Energy Intake, Appetite Sensation, and Energy Expenditure in Healthy Obese Subjects.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the effects of intravenous infusion of two gastrointestinal hormones, PYY3-36 and GLP-1, alone and in combination, on appetite in healthy obese men. The investigators hypothesize that an intravenous infusion of each hormone alone will decrease food intake at a buffet meal and decrease appetite, and that in combination, there will be a greater decrease in food intake and appetite compared to each hormone alone.

Conditions

• Obesity

Interventions

Type	Name	Description
BIOLOGICAL	PYY 3-36	0.8 pmol/kg/min x 3 hours
BIOLOGICAL	GLP-1	1.0 pmol/kg/min x 3 hours
BIOLOGICAL	saline infusion	saline infusion x 3 hours

Timeline

• Start date: 2011-03-01
• Primary completion: 2012-01-01
• Completion: 2012-01-01
• First posted: 2009-07-15
• Last updated: 2012-06-15

Locations

1 site across 1 country: Denmark