NCT00937313

The Pharmacokinetics and Potential Health Effects of Champagne Wine in Human Subjects

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

* To assess whether acute, moderate Champagne wine consumption modulates endothelial function in healthy human volunteers. * To establish the bioavailability of Champagne wine polyphenols and their metabolism.

Detailed description

Subjects refrained from consuming high polyphenol foods for 48 h prior to the start of the study and for 32 h post initiation. In particular, the following foods and beverages were excluded from volunteer diets: cocoa containing products, coffee, tea and wine. The study was designed as a single blind, randomized, crossover intervention trial, where volunteers were asked to consume either 375 ml of Champagne wine or a placebo matched for alcohol content, sugars and fruit-derived acids. Subjects were assessed for anthropometric measurements and provided a urine sample prior baseline Laser Doppler Imaging with iontophoresis (LDI) measurements. Subjects were then cannulated and a baseline blood sample was collected. Subjects were then randomly assigned to either the Champagne wine or placebo group and asked to consume the beverage within a 10 min period. Following a standardised breakfast blood samples were collected at: 15, 30, 45, 60, 120, 180, 240, 300, 360 and 480 minutes post consumption and pooled urine samples were collected over 3 x 8 h periods. A standardised breakfast and lunch were also consumed at 15 and 200 minutes post beverage. LDI measurements were carried out at 120, 240, 360 and 480 minutes. Subjects also provided 24 h and 32 h blood and urine samples. Following a washout period of 28 days, volunteers returned to the unit to complete the second arm of the study where the procedure above was repeated.

Conditions

• No Condition. Assessment of Healthy Volunteers.

Interventions

Type	Name	Description
OTHER	Champagne wine intervention	Placebo-controlled randomised cross-over human trial

Timeline

• Start date: 2007-07-01
• Primary completion: 2008-02-01
• Completion: 2008-09-01
• First posted: 2009-07-13
• Last updated: 2009-07-13

Locations

1 site across 1 country: United Kingdom