Trials / Completed
CompletedNCT00937183
Dendritic Cell Vaccine in Treating Patients With Indolent B-Cell Lymphoma or Multiple Myeloma
Vaccination of Lymphoma Patients With Dendritic Cell-lymphoma Cell Hybrids and Dendritic Cells Pulsed With Tumor Lysates
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 12 (actual)
- Sponsor
- Jan Walewski · Academic / Other
- Sex
- All
- Age
- 18 Years – 120 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Biological therapies, such as a dendritic cell vaccine made with a patient's cancer cells, may stimulate the immune system in different ways and stop cancer cells from growing. PURPOSE: This phase I/II trial is studying the side effects of dendritic cell vaccine and to see how well it works in treating patients with indolent B-cell lymphoma or multiple myeloma.
Detailed description
OBJECTIVES: * Evaluation of feasibility of dendritic cell (DC)-based vaccination program using autologous tumor cells and/or lysates in patients with indolent B cell lymphomas or multiple myeloma as an adjuvant therapy to induce immune response in remission after cytoreductive treatment. * Evaluation of the immune response of patients treated with this regimen. * Evaluation the progression-free survival of patients treated this regimen. * Evaluate the adverse events of this regimen in these patients. OUTLINE: Patients receive intranodal (under ultrasound guidance) or subcutaneous vaccinations of adjuvant electrofusion hybrids of autologous dendritic cells (DC) with autologous lymphoma cells, electrofusion hybrids of allogeneic DC with autologous lymphoma cells, and/or autologous DC pulsed with autologous tumor lysate cells in weeks 0, 2, 4, 8, 12, 18, 26, and 50.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | autologous lymphoma cell lysate-pulsed autologous dendritic cell vaccine | |
| BIOLOGICAL | autologous lymphoma cell/allogeneic dendritic cell electrofusion hybrid vaccine | |
| BIOLOGICAL | autologous lymphoma cell/autologous dendritic cell electrofusion hybrid vaccine |
Timeline
- Start date
- 2003-09-01
- Primary completion
- 2017-06-01
- Completion
- 2017-12-01
- First posted
- 2009-07-10
- Last updated
- 2019-08-19
Locations
1 site across 1 country: Poland
Source: ClinicalTrials.gov record NCT00937183. Inclusion in this directory is not an endorsement.