Trials / Withdrawn
WithdrawnNCT00937144
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
- Status
- Withdrawn
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- Sponsor
- The Baruch Padeh Medical Center, Poriya · Other Government
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Viagra (Sildenafil) | Viagra treatment to patients with sickle cell anemia. |
| DRUG | placebo |
Timeline
- Start date
- 2009-09-01
- Primary completion
- 2009-09-01
- Completion
- 2010-02-01
- First posted
- 2009-07-10
- Last updated
- 2010-03-02
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT00937144. Inclusion in this directory is not an endorsement.