NCT00930007

Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone

Comparison of Sleep-wake LH Frequency in Peripubertal Girls With and Without Hyperandrogenemia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: Female
• Age: 8 Years – 15 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal testosterone levels.

Detailed description

During early puberty, luteinizing hormone (LH) pulse frequency normally increases during sleep. In contrast, preliminary data suggest that obese girls (who have high testosterone levels in general) demonstrate low LH frequency during the day and night during early puberty; but at mid puberty rapidly transition to a high LH frequency during the day and night. We hypothesize that in early pubertal girls with high testosterone levels, overnight increases of LH frequency are less prominent than those observed in early pubertal girls with normal testosterone levels. We will assess this using a frequent sampling protocol for assessment of LH pulse frequency (with sampling occurring while awake and while asleep) in early pubertal girls with and without high testosterone levels. Sleep will be formally evaluated.

Conditions

• Hyperandrogenism

Interventions

Type	Name	Description
OTHER	Blood sampling	Blood sampling for later hormone measurements

Timeline

• Start date: 2008-10-01
• Primary completion: 2023-05-01
• Completion: 2023-08-01
• First posted: 2009-06-30
• Last updated: 2022-05-18

Locations

1 site across 1 country: United States