NCT00929890

Additional Metabolic and Vascular Effects of Exercise in Patients on Diet-based Weight Loss Programs

Effect of Weight Loss Through Dietary Energy Restriction With or Without Exercise on Vascular and Metabolic Parameters in Subjects With Obesity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Hospital de Clinicas de Porto Alegre · Academic / Other
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This study tests the hypothesis that exercise training can confer additional benefit to patients in weight-loss programs in the form of improvements in either metabolic or vascular parameters or both. Patients will be randomized to either diet plus conventional physical activity or diet plus a planned exercise training. The interventions will be carried out until the patients lose between 5% and 7.5% of their initial weight. At entry and at the end, all subjects will be evaluated for outcomes such as blood glucose, lipid profile, insulin, c-reactive protein, fibrinogen, vascular reactivity (doppler ultrasound) and total and abdominal visceral fat (CT-scan). Both groups will be compared.

Conditions

• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	General lifestyle, diet and physical activity counselling	Low-calorie, balanced diet and a general advice on the importance of regular physical activity
BEHAVIORAL	Exercise training	Subject will receive dietary counselling (low-calorie, balanced diet) and will be enrolled in a supervised, 3 times a week, exercise training program

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2009-06-30
• Last updated: 2011-10-26

Locations

1 site across 1 country: Brazil