Trials / Unknown
UnknownNCT00926900
The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes
- Status
- Unknown
- Phase
- Phase 2 / Phase 3
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- Sponsor
- Central Institute of Mental Health, Mannheim · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this project is to explore whether the extinction of cue-reactivity following a cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by drugs that increase NMDA-receptor function. It is hypothesised that targeted treatment with D-Cycloserine prior to each extinction training session enhances the effects on cue-reactivity. Further, a significant correlation between the reduction of cue-reactivity and both reduced craving and relapse probability is expected.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | D-cycloserine | 50 mg at approximately 1.5 hours prior to cue-exposure training sessions |
| DRUG | Placebo | Placebo |
Timeline
- Start date
- 2009-03-01
- Primary completion
- 2012-04-01
- First posted
- 2009-06-24
- Last updated
- 2011-11-28
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT00926900. Inclusion in this directory is not an endorsement.