NCT00926692

Investigations Regarding B-cell Subsets in Humans

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 249 (actual)
• Sponsor: Northwell Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this research is to define the human equivalent of mouse B1 cells.

Detailed description

The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli. The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Blood draw	Subject will have blood draw.

Timeline

• Start date: 2009-04-01
• Primary completion: 2014-07-01
• Completion: 2014-07-01
• First posted: 2009-06-23
• Last updated: 2015-08-26

Locations

1 site across 1 country: United States