NCT00924014

Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure

Comparative Effects of Conivaptan and Loop Diuretics on Plasma Neurohormones and Systemic and Renal Hemodynamics in Subjects With Chronic Congestive Heart Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (estimated)
• Sponsor: Hennepin County Medical Center, Minneapolis · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.

Detailed description

1. To define the hemodynamic, neurohormonal and renal responses to intravenous conivaptan in patients with chronic stable heart failure (HF), and compare these responses to those after intravenous furosemide. 2. To define the hemodynamic, neurohormonal and renal responses to the combination of the two drugs (conivaptan and furosemide).

Conditions

• Heart Failure

Interventions

Type	Name	Description
DRUG	Conivaptan	Conivaptan 20 mg IV bolus followed by a 4 hour infusion at 1.2 mg/hr
DRUG	Furosemide	Furosemide will be given IV at the subjects usual oral dose up to 80 mg. If the dose is 80 mg or more only 1/2 the dose will be given IV.
DRUG	Conivaptan and furosemide	Furosemide bolus first; conivaptan 20 mg IV bolus/infusion at 1.2 mg/hour for a total of 4 hours

Timeline

• Start date: 2009-07-01
• Primary completion: 2009-12-01
• Completion: 2010-03-01
• First posted: 2009-06-18
• Last updated: 2009-06-18

Locations

1 site across 1 country: United States