NCT00923988

Effect of Passive Smoking on Platelet Function and Endothelial Function

Acute Effects of Short-term Exposure to Secondhand Smoke on Platelet Activation and Endothelial Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Kantonsspital Graubünden · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Conditions

• Endothelial Function
• Platelet Aggregation

Interventions

Type	Name	Description
OTHER	secondhand smoke exposure	Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.

Timeline

• Start date: 2009-06-01
• Primary completion: 2009-08-01
• Completion: 2009-08-01
• First posted: 2009-06-18
• Last updated: 2009-08-11

Locations

1 site across 1 country: Switzerland