NCT00921856

Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)

Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (estimated)
• Sponsor: Peter Ong, MD · Academic / Other
• Sex: All
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is suspected depending on the pattern of symptoms and the electrocardiogram (ECG). Coronary angiography is the method of choice to verify this suspicion. If the patient coronary arteries on coronary angiography are totally normal or unobstructed, one can only speculate if the patients' discomfort is from the heart or not. A possibility to get further information about the healthiness of the coronary arteries is the acetylcholine test (ACH-test). When injecting this natural, body produced-substance into the coronary arteries one can test if the vessels develop coronary spasm which can be the reason for the patient's symptoms. The investigators therefore use this test in this study to look for coronary spasm in patients with suspected CAD but normal/unobstructed coronary arteries. In case of a positive test, the patient profits from having found a cause for his/her symptoms making treatment with special tablets possible. Furthermore, the investigators want to analyze blood samples of every patient to look for signs of inflammation, vasoconstriction and genetic variants that seem to be linked with coronary spasms. On the basis of these results the ACH-test could probably be avoided in the future.

Conditions

• Coronary Vasospasm
• Microvascular Angina
• Coronary Artery Disease

Interventions

Type	Name	Description
OTHER	Intracoronary acetylcholine provocation test	Intracoronary provocation of coronary spasm with acetylcholine in augmented dosages of 2 µg, 20 µg, 100 µg and 200 µg non-selectively in the LCA as well as 80 µg in the RCA. During the procedure, a 12 channel ECG will be recorded.

Timeline

• Start date: 2007-11-01
• Primary completion: 2024-12-01
• Completion: 2025-12-01
• First posted: 2009-06-16
• Last updated: 2023-05-31

Locations

1 site across 1 country: Germany