NCT00916045

Pilot Study of Unrelated Cord Blood Transplantation

Pilot Study of Unrelated Cord Blood Transplantation in Patients With Poor Risk Haematological Malignancies

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: King's College Hospital NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the safety and feasibility of unrelated double and single cord blood transplantation in patients with haematological malignancies using reduced-intensity or myeloablative conditioning regimens.

Conditions

• Leukemia, Myeloid, Acute
• Myelodysplastic Syndromes
• Leukemia, Lymphoblastic, Acute
• Lymphoma, Non-Hodgkin
• Hodgkin Disease
• Chronic Lymphocytic Leukemia

Interventions

Type	Name	Description
DRUG	Thiotepa
DRUG	Fludarabine
DRUG	Intravenous busulphan
DRUG	Thymoglobulin
DRUG	Ciclosporin
DRUG	Mycophenolate mofetil (MMF)
DRUG	Fludarabine
DRUG	Cyclophosphamide
RADIATION	Radiotherapy
DRUG	Thymoglobulin
DRUG	Ciclosporin
DRUG	Mycophenolate mofetil (MMF)
DRUG	Fludarabine
DRUG	Melphalan
DRUG	Thymoglobulin
DRUG	Ciclosporin
DRUG	Mycophenolate mofetil (MMF)

Timeline

• Start date: 2009-09-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2009-06-08
• Last updated: 2015-02-11

Locations

1 site across 1 country: United Kingdom