NCT00914147

Lung Function Testing in Patients With Locally Advanced or Metastatic Solid Tumors

Pulmonary Function Tests (PFT) in a Phase I Patient Population

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Barbara Ann Karmanos Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Measuring how well the lungs work in patients with cancer may help doctors predict how patients will respond to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying lung function testing in patients with locally advanced or metastatic solid tumors.

Detailed description

OBJECTIVES: Primary * To obtain the distribution of DLCO, FVC, and FEV\_1 by pulmonary function testing (PFT) in patients with heavily pretreated locally advanced or metastatic solid tumors referred to the Karmanos Cancer Institute (KCI) Phase I Clinical Trials Program. * To estimate the mean DLCO to within 4 units (% of predicted) of the true mean with 95% confidence. Secondary * To estimate the percentage of patients who meet the defined eligibility criteria (including PFT levels, especially DLCO) from the entire population enrolled in the KCI Phase I Clinical Trials Program. OUTLINE: Patients undergo pulmonary function testing comprising spirometry test, lung volumes, and DLCO measurement utilizing the single-breath breath-holding technique. Patients then proceed to treatment on a phase I clinical trial.

Conditions

• Unspecified Adult Solid Tumor, Protocol Specific

Interventions

Type	Name	Description
PROCEDURE	pulmonary function testing	After signing consent, patients will undergo a complete spirometry test, lung volumes and diffusing capacity (DLCO) measurement utilizing the single-breath breath holding technique, according to the ATS/ERS consensus and standardization.

Timeline

• Start date: 2009-05-01
• Primary completion: 2012-08-23
• Completion: 2012-08-23
• First posted: 2009-06-04
• Last updated: 2021-03-08

Locations

1 site across 1 country: United States