NCT00913081

Advancing Niacin by Inhibiting Flushing (ANTI-FLUSH)

Advancing Niacin by Inhibiting FLUSHing: (ANTI-FLUSH)

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Niacin, or vitamin B3, is known to improve cholesterol disorders and is the most effective drug to raise HDL, or the "good cholesterol". The use of niacin has been limited because of a peculiar adverse effect referred to as "flushing', which consists of redness, warmth, tingling and burning. A recent animal study suggests that flavonoids may prevent flushing due to niacin better than drugs like aspirin. The ANTI-FLUSH study is being done to assess whether a presently available dietary supplement known as quercetin, which is a flavonoid, can reduce the flushing that occurs with niacin. We will also assess whether using quercetin to prevent flushing from niacin, can improve how niacin lowers cholesterol.

Detailed description

This study involves people between 21 and 75 years. It will be conducted over a period of 8 weeks, with 4 visits, each separated by 2 weeks. The duration of each visit is 9-10 hours. We will test a different dose of quercetin in each visit.

Conditions

• Flushing

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Quercetin	Quercetin 500, 1000, or 2000 mg PO one time
DIETARY_SUPPLEMENT	Placebo	Placebo PO one time

Timeline

• Start date: 2009-02-01
• Primary completion: 2009-08-01
• Completion: 2009-12-01
• First posted: 2009-06-03
• Last updated: 2015-03-05
• Results posted: 2015-03-05

Locations

2 sites across 1 country: United States