NCT00910988

Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone

A Randomized Comparison of the Acute Effects of Olanzapine and Ziprasidone on Whole Body Insulin Sensitivity in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Primary Aim: To test the acute effects of olanzapine or ziprasidone administration, in comparison to placebo, on insulin sensitivity in antipsychotic-naïve healthy young men, measured as whole-body dextrose infusion rates (mg/kg/min), hepatic glucose production (glucose rate of appearance \[Ra\]), primarily muscle glucose utilization (glucose rate of disappearance \[Rd\]), and adipose tissue related free fatty acid production (glycerol rate of appearance \[Ra\]). We hypothesize that olanzapine, but not ziprasidone, will result in acute decreases in insulin sensitivity. Secondary Aim: To test the acute effects of olanzapine or ziprasidone on insulin signaling pathways in antipsychotic naïve healthy young men. We hypothesize that olanzapine, but not ziprasidone, will result in acute alterations in insulin signaling.

Detailed description

See brief description

Conditions

• Hyperglycemia
• Hyperlipidemia

Interventions

Type	Name	Description
DRUG	Olanzapine	olanzapine/Zyprexa
DRUG	Ziprasidone	ziprasidone/Geodon

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2009-06-01
• Last updated: 2018-07-18
• Results posted: 2014-01-15

Locations

1 site across 1 country: United States