NCT00908622

Study of the Efficacy of Percutaneous Implantation of Autologous Myoblasts in Patients With Old Infarction

Phase II, Blind, Controlled, Randomised Study of the Efficacy of Percutaneous Implantation of Autologous Myoblasts in Patients With Old Infarction

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Clinica Universidad de Navarra, Universidad de Navarra · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is compare the improvement in global and regional cardiac function measured by echocardiography and magnetic resonance in patients with old myocardial infarction subject to cardiac catheterisation with percutaneous endocavity implantation of autologous myoblasts.

Detailed description

Ischaemic heart disease is one of the main causes of mortality and morbidity. In particular, myocardial infarction (MI) is of special significance, as the heart muscle cannot regenerate so a region's necrosis leads to the formation of a fibrous scar. In the last few years, new treatments have been developed for the acute phase of myocardial infarction.We have managed to slow down disease progression with these new treatments, but it continues to the development of end stage heart failure. This study tries to determine the benefit of cell cardiomyoplasty with autologous myoblasts in patients with old MI.

Conditions

• Old Myocardial Infarction

Interventions

Type	Name	Description
PROCEDURE	Percutaneous autologous myoblast implantation	Endocavity implantation of autologous myoblasts
PROCEDURE	Cardiac revascularization	Cardiac revascularization

Timeline

• Start date: 2007-03-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2009-05-27
• Last updated: 2015-09-11

Locations

2 sites across 1 country: Spain