NCT00905931

Lycopene Following Aneurysmal Subarachnoid Haemorrhage

Acute Oral Lycopene Therapy on Cerebral Autoregulation and Delayed Ischaemic Deficits Following Aneurysmal Subarachnoid Haemorrhage (LASH): A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 124 (estimated)
• Sponsor: University of Cambridge · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine whether any improvements translate into a reduction of biochemical markers of vascular injury and inflammation a decrease in the prevalence of secondary strokes following subarachnoid haemorrhage.

Conditions

• Subarachnoid Hemorrhage
• Aneurysm

Interventions

Type	Name	Description
DRUG	Lycopene	30 mg oral, daily, for 21 days
DRUG	placebo	starch

Timeline

• Start date: 2010-09-01
• Primary completion: 2012-06-01
• Completion: 2012-10-01
• First posted: 2009-05-21
• Last updated: 2010-06-11

Locations

1 site across 1 country: United Kingdom