NCT00905892

Metabolic Fate Modifications of Saturated Fats After an Overfeeding

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Centre de Recherche en Nutrition Humaine Rhone-Alpe · Academic / Other
• Sex: Male
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31\_palmitic acid, d31\_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Detailed description

Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31\_palmitic acid, d31\_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Conditions

• Obesity
• Lipid Metabolism
• Inflammation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Hyperlipidic overfeeding	100g per day of cheese + 40g per day of almonds + 20g per day of butter

Timeline

• Start date: 2005-09-01
• Primary completion: 2009-12-01
• Completion: 2010-03-01
• First posted: 2009-05-21
• Last updated: 2011-06-23

Locations

1 site across 1 country: France