NCT00905762

Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After Topical Instillation

A Single-Center, Randomized, Masked Study Comparing the Concentration of Besifloxacin, Gatifloxacin, and Moxifloxacin in Human Conjunctiva After a Single Topical Instillation

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 119 (actual)
• Sponsor: Bausch & Lomb Incorporated · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess the concentration of besifloxacin compared to gatifloxacin and moxifloxacin in human conjunctival tissue, following a single drop of the drug instilled topically into the study eye. Conjunctival biopsies will be performed at specified time points, followed by the use of loteprednol etabonate/tobramycin ophthalmic suspension four times a day for 5 days.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Gatifloxacin	Gatifloxacin 0.3% one drop instilled into study eye at visit 2.
DRUG	Moxifloxacin	Moxifloxacin 0.5% one drop instilled into study eye at visit 2.
DRUG	Besifloxacin	Besifloxacin 0.6% one drop instilled into study eye at visit 2.

Timeline

• Start date: 2009-03-01
• Primary completion: 2009-04-01
• Completion: 2009-04-01
• First posted: 2009-05-21
• Last updated: 2011-12-09

Locations

1 site across 1 country: United States