NCT00902590

A Genotype-Phenotype Urothelial Cancer Registry

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,519 (actual)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer. The investigators will look at risk factors to learn more about how these impact cancer. The investigators will also look at genetic markers. These are genes that are found in a known place. They are often associated with a particular trait. If the gene changes in some way, it may predict cancer or response to treatment. The investigators will look for markers in your saliva. This registry will help us develop better methods of: Preventing these cancers. Diagnosing these cancers. Treating these cancers.

Conditions

• Urothelial Cancer
• Renal Pelvis Cancer
• Ureter Cancer
• Bladder Cancer

Interventions

Type	Name	Description
OTHER	saliva sample and questionaire	Urothelial Cancer Registry- Patients will complete a family history and urothelial cancer risk questionnaire, and will provide a buccal sample for germline DNA. If the cases have undergone germline sequencing as part of Protocol 12-245, they will not need to provide a buccal sample. If the cases have previously completed athe "the "Urothelial Baseline Questionnaire," in an MSKCC urology clinic they will not need to complete the urothelial cancer risk questionnaire.
OTHER	saliva sample, questionaire	Urothelial Cancer Registry- These participants will be requested to complete the risk factor questionnaire and to provide a saliva sample for DNA extraction.

Timeline

• Start date: 2009-05-01
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2009-05-15
• Last updated: 2025-09-05

Locations

4 sites across 1 country: United States