NCT00901745

Interaction of Apelin and Angiotensin in the Human Forearm Circulation

Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.

Conditions

• Heart Disease
• Vasodilation

Interventions

Type	Name	Description
DRUG	Angiotensin II	Infusion of up to 30picmol/ml angiotensin II will be infused and respondent vasoconstriction assessed.
DRUG	Noradrenaline infusion	Infusion of up to 480 picomol/ml of noradrenaline will be infused.

Timeline

• Start date: 2009-05-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2009-05-14
• Last updated: 2010-08-10

Locations

1 site across 1 country: United Kingdom