NCT00900536

DNA Analysis of Blood and/or Tissue Samples From Patients With Primary Kidney Cancer Receiving Sorafenib on Clinical Trial MRC-RE05-SORCE

TRANSORCE (A Sub-study of SORCE)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: —
• Sponsor: Medical Research Council · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood and/or tissue in the laboratory from patients with kidney cancer receiving sorafenib may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to sorafenib. PURPOSE: This research study is looking at the DNA in blood and/or tissue samples from patients with primary kidney cancer receiving sorafenib on clinical trial MRC-RE05-SORCE.

Detailed description

OBJECTIVES: * Examine the relationship between tumor genotype, expression, and patient outcome. * Examine the relationship between constitutional genotype and patient outcome. OUTLINE: This is a multicenter study. Patients undergo blood and/or tissue sample collection for laboratory studies. Laboratory studies include generation of tissue microarrays; analysis of protein expression by immunohistochemistry; tumor DNA extraction and whole genome amplification; detection of VHL or other relevant gene mutations by direct sequencing; and constitutional (lymphocyte DNA) genotyping by single nucleotide polymorphism analysis.

Conditions

• Kidney Cancer

Interventions

Type	Name	Description
GENETIC	mutation analysis
GENETIC	polymorphism analysis
GENETIC	protein expression analysis
OTHER	immunohistochemistry staining method
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2007-07-01
• Completion: 2012-06-01
• First posted: 2009-05-12
• Last updated: 2013-08-12

Locations

1 site across 1 country: United Kingdom