NCT00900406

Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant

Tissue Bank for Studies Related to Graft-Versus-Host Disease (GVHD)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 190 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future. PURPOSE: This research study is collecting and storing tissue and DNA samples from patients undergoing a donor stem cell transplant.

Detailed description

OBJECTIVES: * To establish a DNA bank from donor and recipient (prior to transplant) peripheral blood for SNP studies. * To establish a tissue bank for gene expression studies using donor and recipient (post-transplant) peripheral blood samples. * To establish a tissue bank for proteomic studies using donor and recipient blood and urine samples. * To establish a tissue bank for various studies using biopsy specimens. * To establish a tissue bank for flow cytometric studies using recipient (post-transplant), and sample from stem cell product. OUTLINE: Peripheral blood samples are collected from donors prior to stem cell mobilization and from patients prior to starting preparative regimen. Samples are studied by single nucleotide polymorphism (SNP) analysis, SNP array, proteomic analysis, gene expression, and other immunological laboratory methods. Blood, urine, and tissue samples are preserved for future studies. Extra skin biopsies and gastrointestinal biopsies are performed at diagnosis of graft-vs-host disease and preserved in a tissue bank for flow cytometric studies.

Conditions

• Breast Cancer
• Chronic Myeloproliferative Disorders
• Gestational Trophoblastic Tumor
• Graft Versus Host Disease
• Leukemia
• Lymphoma
• Multiple Myeloma and Plasma Cell Neoplasm
• Myelodysplastic Syndromes
• Myelodysplastic/Myeloproliferative Neoplasms
• Neuroblastoma
• Ovarian Cancer
• Testicular Germ Cell Tumor

Interventions

Type	Name	Description
GENETIC	gene expression analysis	blood collection
GENETIC	microarray analysis	Blood collection
GENETIC	polymorphism analysis	Blood collection
GENETIC	proteomic profiling	Blood collection
OTHER	flow cytometry	Blood collection
OTHER	immunologic technique	Blood collection
OTHER	laboratory biomarker analysis	Blood collection
PROCEDURE	biopsy	Blood collection

Timeline

• Start date: 2007-01-01
• Primary completion: 2010-03-01
• Completion: 2010-03-01
• First posted: 2009-05-12
• Last updated: 2012-11-06

Locations

3 sites across 1 country: United States