NCT00900250

Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma

Hodgkin Disease (HD) Banking Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,271 (actual)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This laboratory study is collecting and storing samples of tissue and blood from young patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help the study of cancer in the future.

Detailed description

OBJECTIVES: I. Establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma. II. Provide specimens from diagnosis, early response evaluation, completion of chemotherapy and radiotherapy, long-term follow up, and relapse to study prognostic factors for early response, relapse, long-term outcomes, and identification of new biological targets for therapy. OUTLINE: This is a multicenter study. Patients enrolled on Hodgkin's lymphoma (HL) therapeutic clinical trials undergo collection of tumor tissue samples at baseline and at relapse or disease progression. Serum and anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after diagnosis, and at relapse or disease progression. Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral blood samples at relapse or disease progression. Patients enrolled more than 1 year after completion of treatment undergo collection of tumor specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation.

Conditions

• Ann Arbor Stage I Childhood Hodgkin Lymphoma
• Ann Arbor Stage II Childhood Hodgkin Lymphoma
• Ann Arbor Stage III Childhood Hodgkin Lymphoma
• Ann Arbor Stage IV Childhood Hodgkin Lymphoma
• Refractory Childhood Hodgkin Lymphoma

Interventions

Type	Name	Description
OTHER	Cytology Specimen Collection Procedure	Correlative studies

Timeline

• Start date: 2006-10-23
• Primary completion: 2019-03-31
• Completion: 2019-03-31
• First posted: 2009-05-12
• Last updated: 2019-04-10

Locations

183 sites across 4 countries: United States, Australia, Canada, Switzerland