Trials / Terminated
TerminatedNCT00900068
Blood Samples From Patients on a Clinical Trial to CINV During HSCT
Substance P Follow-up to a Pilot Study of Aprepitant vs Placebo Combined With Standard Antiemetics for the Control of Nausea and Vomiting During Hematopoietic Cell Transplantation
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 9 (actual)
- Sponsor
- OHSU Knight Cancer Institute · Academic / Other
- Sex
- All
- Age
- 18 Years – 120 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of blood in the laboratory from patients with cancer may help doctors learn more about nausea and vomiting caused by cancer treatment. PURPOSE: This laboratory study is looking at blood samples from patients with cancer who were treated on a clinical trial to control nausea and vomiting during donor stem cell transplant.
Detailed description
OBJECTIVES: Primary * To compare the amount of substance P in serum samples from patients with cancer treated with busulfan/cyclophosphamide or cyclophosphamide/total body irradiation conditioning regimens prior to undergoing allogeneic hematopoietic stem cell transplantation. Secondary * To assess the changes in substance P over time to see if there is an optimal time shown by this physiologic correlate to discontinue substance P blockade after the chemotherapy regimen is completed in these patients. OUTLINE: Previously collected serum samples are analyzed by enzyme immunoassay for changes in substance P levels. Patients' medical records are reviewed for demographic information, past history, and course of treatment.
Conditions
- Breast Cancer
- Chronic Myeloproliferative Disorders
- Gestational Trophoblastic Tumor
- Leukemia
- Lymphoma
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
- Myelodysplastic/Myeloproliferative Neoplasms
- Nausea and Vomiting
- Neuroblastoma
- Ovarian Cancer
- Testicular Germ Cell Tumor
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | immunoenzyme technique | |
| OTHER | laboratory biomarker analysis | |
| OTHER | medical chart review |
Timeline
- Start date
- 2008-08-01
- Primary completion
- 2009-08-01
- Completion
- 2009-10-01
- First posted
- 2009-05-12
- Last updated
- 2017-05-09
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00900068. Inclusion in this directory is not an endorsement.