Trials / Completed
CompletedNCT00900055
Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma
Dysregulation of Hematopoiesis in Fanconi Anemia
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 213 (actual)
- Sponsor
- OHSU Knight Cancer Institute · Academic / Other
- Sex
- All
- Age
- 1 Year – 55 Years
- Healthy volunteers
- Accepted
Summary
RATIONALE: Analyzing tissue and blood samples from healthy volunteers or patients with Fanconi anemia, myelodysplasia, myeloproliferative disorders, or myeloma in the laboratory may help doctors learn more about the causes of blood cancers. PURPOSE: The purpose of this study is to analyze in the laboratory blood and bone marrow cells from healthy volunteers or patients with Fanconi anemia, myeloproliferative disorders, or myeloma.
Detailed description
OBJECTIVES: * Identify the specific molecular function of the Fanconi anemia (FA) complementing gene products in hematopoietic progenitor cells from patients and normal volunteers. * Identify functional defects in hematopoietic stromal cells, including macrophages, from patients with FA, and selected blood cancers as well as normal volunteers. OUTLINE: Peripheral blood mononuclear leukocytes, skin fibroblasts, and marrow fibroblasts are collected for loss-of-function and gain-of-function analysis related to the Fanconi anemia complementing gene.
Conditions
- Chronic Myeloproliferative Disorders
- Fanconi Anemia
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic/Myeloproliferative Neoplasms
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | microarray analysis | |
| GENETIC | polyacrylamide gel electrophoresis | |
| GENETIC | polymerase chain reaction | |
| GENETIC | protein expression analysis | |
| GENETIC | reverse transcriptase-polymerase chain reaction | |
| GENETIC | western blotting | |
| OTHER | chromatography | |
| OTHER | high performance liquid chromatography | |
| OTHER | immunoenzyme technique |
Timeline
- Start date
- 1975-06-01
- Primary completion
- 2016-08-23
- Completion
- 2016-08-23
- First posted
- 2009-05-12
- Last updated
- 2022-07-05
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00900055. Inclusion in this directory is not an endorsement.