NCT00900042

SWOG-9023, DNA Analysis of Tumor Tissue From Patients With Metastatic Kidney Cancer

Cytogenetic and Flow Cytometric Analysis of : Renal Cell Carcinoma: A Companion Protocol to SWOG-8949

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: SWOG Cancer Research Network · Network
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: DNA analysis of tumor tissue may help doctors predict how well patients will respond to treatment. PURPOSE: This laboratory study is analyzing the DNA in tumor tissue from patients with metastatic kidney cancer.

Detailed description

OBJECTIVES: * Determine if cytogenetic abnormalities can predict clinical outcome, in terms of response to treatment and survival, in patients with metastatic renal cell carcinoma registered to the nephrectomy arm (arm I) of SWOG-8949. * Correlate cytogenetic abnormalities and DNA content analysis (DNA index and S-phase fraction) with clinical outcome. OUTLINE: This is a partially prospective, partially retrospective, multicenter, companion study. Paraffin-embedded tumor tissue specimens from patients enrolled in SWOG-8949 are evaluated by cytogenetic analysis (e.g., presence of trisomy and loss of Y chromosome) and flow cytometric analysis (e.g., presence of nondiploid cells and presence of abnormal proliferation index). PROJECTED ACCRUAL: A total of 80 patients will be accrued for this study.

Conditions

• Kidney Cancer

Interventions

Type	Name	Description
GENETIC	DNA ploidy analysis
GENETIC	DNA stability analysis
GENETIC	chromosomal translocation analysis
GENETIC	cytogenetic analysis
OTHER	flow cytometry
OTHER	laboratory biomarker analysis

Timeline

• Start date: 1993-07-01
• Primary completion: 2002-12-01
• Completion: 2003-01-01
• First posted: 2009-05-12
• Last updated: 2014-02-25