NCT00899665

Proteases in Patients With Prostate Cancer That Has Spread to the Bone

Proteases in Prostate Cancer Bone Metastasis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 31 (actual)
• Sponsor: Barbara Ann Karmanos Cancer Institute · Academic / Other
• Sex: Male
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Collecting and storing samples of bone marrow and tissue from patients to test in the laboratory may help the study of cancer. PURPOSE: This laboratory study is comparing proteases (enzymes that break down protein) in patients with prostate cancer that has spread to the bone with patients who do not have cancer that has spread to the bone.

Detailed description

OBJECTIVES: * Examine the roles of proteases and protease-associated molecules in bone metastases in patients with metastatic prostate cancer. OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography and/or Western blot analysis, and gene profiling analysis in order to visualize and quantitate protease or protease-related levels. PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.

Conditions

• Anemia
• Metastatic Cancer
• Myelodysplastic Syndromes
• Precancerous Condition
• Prostate Cancer

Interventions

Type	Name	Description
GENETIC	fluorescence in situ hybridization
GENETIC	microarray analysis
GENETIC	molecular diagnostic method
OTHER	immunohistochemistry staining method
OTHER	laboratory biomarker analysis
PROCEDURE	biopsy
PROCEDURE	immunoscintigraphy

Timeline

• Start date: 2001-07-01
• Primary completion: 2006-09-01
• Completion: 2008-01-01
• First posted: 2009-05-12
• Last updated: 2014-02-11

Locations

1 site across 1 country: United States