NCT00899535

Cancer Genome Study Using Samples From Patients With Stage I or Stage II Non-Small Cell Lung Cancer Treated on Clinical Trial ACOSOG-Z0030

The Cancer Genome Atlas (TCGA) Utilizing Z0030 NSCLC Patient Samples

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Alliance for Clinical Trials in Oncology · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at the cancer genome using tumor samples from patients with stage I or stage II non-small cell lung cancer treated on clinical trial ACOSOG-Z0030.

Detailed description

OBJECTIVES: * To investigate the clinical relevance of conducting comprehensive molecular analyses on clinically annotated high-quality tumor biospecimens from patients with stage I or II, N0 or N1 (less than hilar) non-small cell lung cancer. OUTLINE: This is a multicenter study. Biological specimens are collected from participating clinical sites and analyzed by transcription profiling of RNA and microRNA; detection of DNA copy number changes and chromosomal rearrangements; epigenetic modifications analyses; and sequencing of genomic segments, genes, and regulatory regions to assess sequence variation. Clinical information associated with each specimen donor is also collected.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
GENETIC	DNA analysis
GENETIC	RNA analysis
GENETIC	microarray analysis
GENETIC	mutation analysis
GENETIC	polymorphism analysis

Timeline

• Start date: 2008-10-01
• Primary completion: 2010-10-01
• Completion: 2013-02-01
• First posted: 2009-05-12
• Last updated: 2016-06-29