NCT00899457

Molecular Markers in Predicting Lung Cancer Development Using Tissue Samples From Healthy Participants

Molecular Predictors of Lung Cancer Behavior: Controls

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer. PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.

Detailed description

OBJECTIVES: * To obtain biological specimens from healthy participants with no known risk of lung cancer to use as controls in the study of lung cancer progression. * To identify new molecular abnormalities specific to the development of squamous cell carcinoma of the lung. OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.

Conditions

• Healthy, no Evidence of Disease
• Lung Cancer

Interventions

Type	Name	Description
GENETIC	proteomic profiling	Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
OTHER	biologic sample preservation procedure	Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
OTHER	laboratory biomarker analysis	Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
PROCEDURE	bronchoscopy	Collection of breath condensate.

Timeline

• Start date: 2008-04-01
• Primary completion: 2010-08-01
• Completion: 2010-08-01
• First posted: 2009-05-12
• Last updated: 2014-06-24

Locations

3 sites across 1 country: United States