NCT00898950

Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes

The Links Between Dysglycaemia, Insulin Resistance, Endothelial Function, Inflammation and Oxidative Stress: Effect of Different Doses of Aspirin in Subjects With Type-2 Diabetes and High Cardiovascular Risk

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Portsmouth · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study was set up to assess the effects of different doses of aspirin when compared with placebo (dummy drug), used sequentially over a 2 week study period with a 2 week wash-out (rest period) in between, in people with type-2 diabetes and high cardiovascular risk. Specifically, its effects on different factors which are thought to contribute to diabetes such as insulin resistance (body's ability to effectively use insulin), dysglycaemia (excess glucose in the blood), oxidative stress (effects from accumulation of by-products of metabolism), endothelial function (function of lining of blood vessels) and inflammation were studied.

Conditions

• Diabetes Type 2

Interventions

Type	Name	Description
DRUG	Aspirin	Aspirin 75mgs/day orally for 2 weeks.
DRUG	Aspirin	300mgs/day orally for 2 weeks
DRUG	Aspirin	aspirin 900mgs QID orally for 2 weeks
OTHER	placebo tablet	placebo tablet with lactose and excipients.

Timeline

• Start date: 2004-08-01
• Primary completion: 2006-07-01
• Completion: 2006-07-01
• First posted: 2009-05-12
• Last updated: 2009-05-12

Locations

2 sites across 1 country: United Kingdom