NCT00898040

Study of DNA Samples From Patients With Multiple Myeloma

Proposal for Combining ECOG Myeloma Trial SNP Data

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 600 (actual)
• Sponsor: ECOG-ACRIN Cancer Research Group · Network
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA samples from patients with multiple myeloma.

Detailed description

OBJECTIVES: * Determine whether there is an increased frequency of 1 or more polymorphic alleles that are associated with clinical endpoints using custom myeloma single nucleotide polymorphism (SNP) chip analysis of banked DNA samples from patients with multiple myeloma. * Determine SNPs associated with toxicities caused, not by variations in tumor cell genetics, but by individual genetic variations affecting drug activation, distribution, metabolism, and export (ADME). * Determine SNPs associated with response, influenced by the same ADME. * Determine SNPs associated with bone disease (as a variable) among patients with multiple myeloma. * Determine SNPs associated with epidemiology (i.e., risk factors for the development of multiple myeloma). OUTLINE: This is a retrospective, multicenter study. Banked DNA samples are analyzed using a custom single nucleotide polymorphism (SNP) chip to assess approximately 3,590 SNPs from 1,061 genes that are associated with myeloma growth and response. PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Conditions

• Multiple Myeloma and Plasma Cell Neoplasm

Interventions

Type	Name	Description
GENETIC	polymorphism analysis

Timeline

• Start date: 2006-07-06
• Primary completion: 2007-01-01
• Completion: 2007-01-01
• First posted: 2009-05-12
• Last updated: 2017-05-19