NCT00897754

Gene Expression in Patients With Advanced or Metastatic Colorectal Cancer Receiving Bevacizumab

Alternative Splice Forms of VEGF in Colorectal Cancer - Possible Value in Anti-VEGF Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: ECOG-ACRIN Cancer Research Group · Network
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors understand how patients respond to treatment. PURPOSE: This laboratory study is looking at gene expression in patients with advanced or metastatic colorectal cancer receiving bevacizumab.

Detailed description

OBJECTIVES: * Determine whether the balance of splice form expression alters susceptibility of tumors in vivo to respond to anti-VEGF therapy. OUTLINE: Tumor tissue samples collected on clinical trial E-3200 are analyzed for laboratory endpoints.

Conditions

• Colorectal Cancer

Interventions

Type	Name	Description
GENETIC	gene expression analysis
GENETIC	protein expression analysis
GENETIC	reverse transcriptase-polymerase chain reaction
OTHER	immunoenzyme technique
OTHER	immunohistochemistry staining method
OTHER	immunologic technique

Timeline

• Start date: 2007-07-24
• Primary completion: 2009-02-01
• Completion: 2009-02-01
• First posted: 2009-05-12
• Last updated: 2017-05-19