NCT00897494

Identification of Biomarkers for Early Detection of Pancreatic Cancer

Michigan Center for Pancreatic Cancer Molecular Diagnosis: The Serum Protein Microarray Project

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 75 (actual)
• Sponsor: Barbara Ann Karmanos Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is examining blood samples from patients with cancer to identify biomarkers that may help in the early detection of pancreatic cancer.

Detailed description

OBJECTIVES: * Identify specific proteins of interest to evaluate for their potential role as markers for pancreatic cancer. * Analyze serum proteins directly by mass spectrometry to identify new biomarkers of pancreatic cancer that can be used for early diagnosis. OUTLINE: Blood from patients is collected prior to treatment. Plasma proteins are analyzed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and/or electrospray mass spectrometry (ESI/MS). PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.

Conditions

• Pancreatic Cancer

Interventions

Type	Name	Description
GENETIC	protein expression analysis	Venous blood collection
OTHER	laboratory biomarker analysis	Venous blood collection
OTHER	mass spectrometry	Venous blood collection
OTHER	surface-enhanced laser desorption/ionization-time of flight mass spectrometry	Venous blood collection

Timeline

• Start date: 2005-02-01
• Primary completion: 2009-11-01
• Completion: 2011-04-01
• First posted: 2009-05-12
• Last updated: 2016-03-09

Locations

1 site across 1 country: United States