Trials / Completed
CompletedNCT00897468
Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer
Developing In-Vivo Models of Human Breast Cancer
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 26 (actual)
- Sponsor
- Vanderbilt-Ingram Cancer Center · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.
Detailed description
OBJECTIVES: * To develop new in vivo models of human breast cancer. * To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible. OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics. Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells. |
| OTHER | medical chart review | patient chart review will occur in conjunction with patient data collection for final analyses. |
Timeline
- Start date
- 2007-02-01
- Primary completion
- 2018-05-01
- Completion
- 2018-05-01
- First posted
- 2009-05-12
- Last updated
- 2018-05-04
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00897468. Inclusion in this directory is not an endorsement.