NCT00897260

Umbilical Cord Blood Transplantation As Treatment Of Adult Patients With Hematologic Disorders

Umbilical Cord Blood Transplantation as Treatment of Adult Patients With Hematologic Disorders

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To determine the time to and rate of hematologic engraftment following unrelated umbilical cord blood transplantation in adults with one or two cord blood units using total body irradiation and fludarabine as the transplant conditioning regimen and cyclosporine/MMF as graft-versus-host disease prophylaxis.

Conditions

• Hematological Malignancy
• Bone Marrow Failure Syndrome

Interventions

Type	Name	Description
DRUG	Umbilical Cord Blood Transplantation as Treatment of Adult Patients with Hematologic Disorders	To determine the time to and rate of hematologic engraftment following unrelated umbilical cord blood transplantation in adults with one or two cord blood units using total body irradiation and fludarabine as the transplant conditioning regimen and cyclosporine/MMF as graft-versus-host disease prophylaxis. DRUG/DOSE DAYS -9 -8, -7 -6 -5 -4 -3 -2 -1 Total Body Irradiation 150 cGy per treatment (1350cGy total) 2x 2x 2x 2x 1x * Fludarabine 40mg/m2 10:00am (After TBI) over 60 minutes x x x x Umbilical cord blood infusion (minimum of 24hrs after Flu infusion) x * Fludarabine dose adjustment: 70ml/min: decrease dose by Creatinine Clearance 20% Fludarabine dosing will be based on the 40% adjusted ideal body weight. UCB Infusion
RADIATION	Umbilical Cord Blood Transplantation as Treatment of Adult Patients with Hematologic Disorders	DRUG/DOSE DAYS -9 -8, -7 -6 -5 -4 -3 -2 -1 Total Body Irradiation 150 cGy per treatment (1350cGy total) 2x 2x 2x 2x 1x
PROCEDURE	Umbilical Cord Blood Transplantation as Treatment of Adult Patients with Hematologic Disorders

Timeline

• Start date: 2009-05-01
• Primary completion: 2013-01-09
• Completion: 2013-01-09
• First posted: 2009-05-12
• Last updated: 2018-01-26

Locations

1 site across 1 country: Canada