NCT00896740

Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants

Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: OHSU Knight Cancer Institute · Academic / Other
• Sex: All
• Age: 1 Year – 55 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi anemia. PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients with Fanconi anemia and from healthy participants.

Detailed description

OBJECTIVES: * Describe the complete hematopoietic transcriptomes of Fanconi cells of every common complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic cells derived from bone marrow of patients with Fanconi anemia. * Define large-scale dynamic gene expression data in these patients. OUTLINE: This is a multicenter study. Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological studies. Samples are analyzed for gene expression profiles using microarray assays. PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this study.

Conditions

• Fanconi Anemia

Interventions

Type	Name	Description
GENETIC	microarray analysis
PROCEDURE	biopsy

Timeline

• Start date: 2002-03-01
• Primary completion: 2007-09-01
• Completion: 2007-09-01
• First posted: 2009-05-12
• Last updated: 2017-12-04

Locations

1 site across 1 country: United States