NCT00895843

Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery

Protective Analgesia Using Bupivacaine and Conventional Release Ibuprofen Versus Bupivacaine and Sustained Release Ibuprofen for Postoperative Pain Relief in Patients Undergoing Third Molar Surgery: a Randomised Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 122 (actual)
• Sponsor: University of Manchester · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether robust analgesic regime (protective analgesia) can improve postoperative pain experience for patients undergoing lower wisdom teeth extraction under day case general anaesthetic.

Detailed description

The aim of the study was to demonstrate and improve postoperative pain experience using protective analgesia for patients undergoing oral surgery under day case general anaesthesia. The primary objective was to investigate the efficiency of protective analgesia using combined effects of sustained release ibuprofen and bupivacaine nerve block in attenuation of postoperative pain following impacted third molar surgery under day case general anaesthesia. The secondary objective was to document the safety and tolerability profile of conventional release versus sustained released ibuprofen with bupivacaine block in subjects undergoing impacted third molar surgery under day case general anaesthesia.

Conditions

• Postoperative Pain
• Wisdom Tooth

Interventions

Type	Name	Description
DRUG	Brufen retard	Single dose 2 x 800mg tablets 2 hours prior to surgery
DRUG	ibuprofen	Single dose ibuprofen 2 x 200mg tablets 2 hours prior to surgery
DRUG	Bupivacaine	Up to 10ml of Bupivacaine 0.5% with 1:200,000 Adrenaline given prior to surgical incision as inferior alveolar nerve block and long buccal nerve infiltration.

Timeline

• Start date: 2006-11-01
• Primary completion: 2007-12-01
• Completion: 2008-01-01
• First posted: 2009-05-08
• Last updated: 2009-06-01
• Results posted: 2009-05-08

Locations

2 sites across 1 country: United Kingdom