NCT00893659

Beta-glucan on Fecal Microflora in Polypectomized Patients

The Effect of Beta-glucan on Faecal Microflora in Polypectomized Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: Harokopio University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine the effect of the potential prebiotic beta-glucan on the intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and beta-glucosidase) in the feces, the fecal pH and the concentration of fecal short-chain fatty acid in polypectomized patients. Also the in vitro anti-cyto- and anti-genotoxicity of fecal water will be examined on human cell culture (HT29). During the trial, patient's clinical symptoms (intestinal habits), physical activity, well-being and food intake will be recorded.

Detailed description

Prebiotics, such as short- and long-chain fructo-oligosaccharides are fermented by the microflora colonizing the gastrointestinal tract, and they selectively stimulate the growth or the activity of one or limited number of bacteria within the intestine. Beta-glucans are polysaccharides occurring in the bran of cereal grains, the cell wall of Saccharomyces cerevisiae and bacteria, certain types of fungi, seaweed and many kinds of mushrooms. The aim of this study is to determine the effect of the potential prebiotic beta-glucan on the intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and beta-glucosidase) in the faeces, the faecal pH, and the concentration of faecal short-chain fatty acid in polypectomized patients.

Conditions

• Polypectomized Patients

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	wheat bread with beta-glucan	3 g beta-glucan in approximately 200 g of wheat bread per day for 3 months
DIETARY_SUPPLEMENT	wheat bread without beta-glucan	Approximately 200 g of wheat bread (without beta-glucan supplementation) per day for 3 months

Timeline

• Start date: 2009-01-01
• Primary completion: 2012-12-01
• Completion: 2015-07-01
• First posted: 2009-05-06
• Last updated: 2015-07-24

Locations

1 site across 1 country: Greece