NCT00892307

Adenosine Dual Source Computed Tomography (CT) Versus Adenosine Single Photon Emission Computed Tomography (SPECT)

Coronary Anatomy and Physiology Using Multidetector Dual Source Computed Tomography With Adenosine Enhancement: Comparative Study With SPECT Imaging: Pilot Studies I/II

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Researchers hope that this new non-invasive multi-detector scanner (DSCT) will provide diagnostic information comparable to the combination of traditional SPECT (for function and blood flow) and CT imaging (for a precise anatomical view).

Detailed description

The DSCT scanner is able to assess cardiac blood flow (myocardial perfusion) at the same time as coronary anatomy. The results derived from these scans will be compared to standard SPECT imaging. To further evaluate obstruction in the coronary arteries, physicians may refer for an invasive Coronary Angiogram, the current gold standard for diagnosis of Coronary Artery Disease (CAD). By validating the DSCT scanner as a system with which to assess the extent of obstruction in the coronary arteries, physicians may be able to lessen the occurrence of an invasive exam. Procedures: Each pilot anticipates enrolling 20 subjects. Pilot 1: Clinical Follow-up Rest/Stress Adeno-SPECT and Research Stress /Rest Adeno-DSCT obtained in the same patient during the same period of stress testing * Radiation: Thallium injection for rest SPECT * Drug: Single dose Adenosine Infusion for DSCT and SPECT * Radiation: Sestamibi injection for stress SPECT * Drug: CT contrast * Radiation: Stress DSCT /Rest DSCT Pilot 2: Research Stress/ Rest Adeno-DSCT obtained within 30 days of initial positive SPECT finding * Drug: Adenosine Infusion for DSCT * Drug: CT contrast * Radiation: Stress DSCT /Rest DSCT Both pilot studies will relate results to subject history, ECG and cardiac angiogram, if available

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
RADIATION	Dual Source Multidetector CT (DSCT) w/ Adenosine enhancement	Somatom Definition Dual Source CT Scanner Stress/Rest Image scan using weight based CT contrast dye

Timeline

• Start date: 2007-02-01
• Primary completion: 2010-02-01
• Completion: 2011-05-01
• First posted: 2009-05-04
• Last updated: 2013-11-13

Locations

1 site across 1 country: United States