NCT00890708

Therapeutic Drug Monitoring of Voriconazole

Influence of Therapeutic Drug Monitoring of Voriconazole on Incidence of Drug Adverse Reaction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether therapeutic drug monitoring of voriconazole is useful in the treatment of invasive fungal infection.

Detailed description

Voriconazole is an anti-fungal agent, which is used in the treatment of invasive fungal infection, especially aspergillosis. The serious side effects of voriconazole include liver function abnormality, encephalopathy, etc. Recently, the several studies showed that the blood level of voriconazole is variable and it is associated with drug side effect and treatment outcome. However, there is no randomized controlled study which proves that therapeutic drug monitoring of voriconazole can improve the clinical outcome in routine clinical practice.

Conditions

• Mycoses

Interventions

Type	Name	Description
DRUG	Voriconazole (therapeutic drug monitoring)	dosage adjustment according to trough level of voriconazole in plasma

Timeline

• Start date: 2008-11-01
• Primary completion: 2011-12-01
• Completion: 2012-02-01
• First posted: 2009-04-30
• Last updated: 2012-02-22

Locations

1 site across 1 country: South Korea