NCT00888186

Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 30 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.

Detailed description

By using duodenal infusion of levodopa/carbidopa, the plasma concentration of levodopa can be kept fairly constant. Different doses, 10-20% higher or lower than the individually optimized dose will be used. Motor performance is captured by video recordings to be compared to/correlated with plasma levodopa concentrations.

Conditions

• Parkinson Disease
• Dyskinesias

Interventions

Type	Name	Description
DRUG	levodopa/carbidopa	intestinal gel, for continuous daytime infusion

Timeline

• Start date: 2008-02-01
• Primary completion: 2008-05-01
• Completion: 2008-05-01
• First posted: 2009-04-27
• Last updated: 2009-04-27

Locations

1 site across 1 country: Sweden