NCT00887302

Metabolomics of Roux-en-Y Gastric Bypass (RYGB) With Gastrostomy

Johnson and Johnson Ethicon Metabolomics of RYGB With Gastrostomy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: East Carolina University · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study is an investigation of the "metabolomics of RYGB with gastrostomy."

Detailed description

The rapid and durable remission of type II diabetes mellitis following the gastric bypass operation challenges the current concepts about the etiology of the disease. The surgery, which excludes food from the stomach, duodenum, and proximal jejunum, is quickly followed by a durable drop in glucose and insulin levels. As a result, 4 out of 5 diabetic, morbidly obese individuals who undergo the operation return to a long-term euglycemia with a prolongation of life and a reduction of health care costs. The investigators at East Carolina University and those at Johnson and Johnson propose to further complete the profile of the upper gut by extending their observation to three additional human models. The investigators will study patients having the gastric band procedure, the gastric sleeve procedure, and those who have a gastric bypass but have a PEG tube inserted later.

Conditions

• Type II Diabetes Mellitus
• Obesity

Interventions

Type	Name	Description
PROCEDURE	Gastric Band	Places a band over the upper portion of the stomach.
PROCEDURE	Gastric Sleeve	Stapling stomach vertically to reduce size of stomach and removal of larger curve portion of the stomach
PROCEDURE	Gastrostomy Tube	Tube is inserted into the stomach that delivers nutrition directly into the stomach.

Timeline

• Start date: 2009-03-25
• Primary completion: 2012-10-12
• Completion: 2012-10-12
• First posted: 2009-04-23
• Last updated: 2023-10-06

Locations

1 site across 1 country: United States