NCT00884039

Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients

Compassionate Use of Anecortave Acetate: Clinical Protocol for the Treatment of Corticosteroid-induced Intraocular Pressure (IOP) Increases After Corneal Transplantation

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Cornea Research Foundation of America · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the use of anecortave acetate injection to reduce intraocular pressure (IOP) in corneal transplant recipients who are experiencing steroid-associated pressure control problems. Alternative methods of IOP control have been shown to entail serious risks. For example, reduction of topical steroids increases the risk of graft rejection, and use of glaucoma medications or glaucoma surgery increases the risk of graft failure. This study is designed to have sufficient power to detect whether a single injection can induce a clinically significant IOP reduction.

Conditions

• Transplant
• Intraocular Pressure

Interventions

Type	Name	Description
DRUG	anecortave acetate	anterior juxtascleral depot of 15 mg anecortave acetate
DRUG	30 mg anecortave acetate	anterior juxtascleral depot of 30mg anecortave acetate

Timeline

• Start date: 2009-05-01
• Primary completion: 2010-08-01
• Completion: 2010-09-01
• First posted: 2009-04-20
• Last updated: 2018-08-14
• Results posted: 2010-11-17

Locations

1 site across 1 country: United States