NCT00883467

The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Ischemia reperfusion injury may be reduced by ischemic preconditioning. This projects aims to show the effects of short and long time ischemic preconditioning (both sequences 3 x 5 minutes) during and after an ischemic period of 20 minutes in healthy subjects by functional MRI. Ischemia is produces by cuff inflation to a suprasystolic pressure on one tight. Signal is acquired from calf muscles. A cross-over design of 4 to 8 study periods is used, 4 different study days with 2 different MR measurement methods (BOLD imaging and high energy phosphates) are planned.

Conditions

• Ischemia

Interventions

Type	Name	Description
PROCEDURE	preconditioning	3 times of five minutes ischemia, produced by cuff inflation to a suprasystolic pressure positioned on the thigh
PROCEDURE	no preconditioning	no preconditioning

Timeline

• Start date: 2008-05-01
• Primary completion: 2009-06-01
• First posted: 2009-04-17
• Last updated: 2009-04-17

Locations

1 site across 1 country: Austria