NCT00880347

Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia

Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia : A Prospective Study for a Blood Diagnostic Test in Alzheimer's Disease - (Protocol n° EHTAD/002).

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 550 (estimated)
• Sponsor: Exonhit · Industry
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The objective of the study is to define the performance of blood-based signatures for Alzheimer's Disease (AD) in different patients populations including AD, non-AD dementia, and non-demented controls.

Detailed description

The main objective of the study is to define the performance of blood-based transcriptomic signatures for AD, identified using SpliceArray tm technology, in the intended use population of patients suffering from dementia, including AD and the most common non-AD dementia (Lewy Bodies dementia, vascular dementia, fronto-temporal dementia, dementia due to Parkinson's Disease, and mixed dementia). A group of non-demented subjects will serve as a control reference.

Conditions

• Alzheimer's Disease
• Dementia

Interventions

Type	Name	Description
DEVICE	Blood sampling	Venous blood sampling in PaxGene tubes intended to collect blood RNA that will be then analyzed using SpliceArray (tm) technology for transcriptomic profile. sAPPalpha levels will be also dosed. Clinical data to be collected in parallel (medical history, concomitant treatment, MMSE,clinical examination,...)

Timeline

• Start date: 2008-02-01
• Primary completion: 2011-02-01
• Completion: 2011-02-01
• First posted: 2009-04-13
• Last updated: 2011-03-31

Locations

21 sites across 1 country: France