NCT00876811

Effect of Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers

Raspberries and Human Health: A Short-term Intervention Trial Investigating the Effect of Daily Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 18 Years – 43 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult population.

Detailed description

Red raspberries are an excellent source of numerous polyphenolic antioxidants. The bioactivity of these compounds have been implicated in many biological pathways and may function to reduce the risk of numerous chronic diseases. We are conducting an intervention study with frozen red raspberries on a healthy adult population in order to determine if raspberry polyphenols are bioavailable and bioactive in vivo. Twenty-four subjects (12 male and 12 female) will be recruited to participate and consume one-cup frozen red raspberries daily for two weeks, they then will randomly be assigned to consume either one, two or four cups of raspberries for another two weeks, this will be followed by four weeks of non-treatment. Blood samples and 12-hour urine collections will be taken in order to measure the concentration of raspberry polyphenols in response to treatment dose. Dose-dependent treatment effects on blood biomarkers for antioxidant capacity, oxidative stress, inflammation and other chronic disease risk factors will also be measured.

Conditions

• Oxidative Stress

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	individually quick frozen red raspberries	Consumption of one-cup frozen red raspberries daily for four weeks, followed by a four week period of non-treatment.
DIETARY_SUPPLEMENT	individually quick frozen red raspberries	Consumption of one-cup frozen red raspberries for two weeks, then consumption of two-cups frozen red raspberries for an additional two weeks, followed by four weeks of non-treatment.
DIETARY_SUPPLEMENT	individually quick frozen red raspberries	Consumption of one-cup frozen red raspberries for two weeks, then consumption of four-cups frozen red raspberries for an addition two weeks, followed by four weeks of non-treatment.

Timeline

• Start date: 2009-03-01
• Primary completion: 2009-05-01
• Completion: 2009-05-01
• First posted: 2009-04-07
• Last updated: 2010-10-29

Locations

1 site across 1 country: Canada